Gentian violet exhibits activity against biofilms formed by oral Candida isolates obtained from HIV-infected patients.

نویسندگان

  • Rana S Traboulsi
  • Pranab K Mukherjee
  • Jyotsna Chandra
  • Robert A Salata
  • Richard Jurevic
  • Mahmoud A Ghannoum
چکیده

The effect of gentian violet against Candida albicans and non-Candida albicans biofilms formed on polymethylmethacrylate strips was evaluated using a dry weight assay and confocal laser scanning microscopy. The ability of gentian violet to inhibit Candida albicans germination was also assessed. Gentian violet activity against Candida biofilms was demonstrated by a reduction in dry weight, disruption of biofilm architecture, and reduced biofilm thickness. Additionally, gentian violet inhibited Candida germination in a concentration-dependent manner.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 55 6  شماره 

صفحات  -

تاریخ انتشار 2011